Department of Chemistry Ming Xian Research Group

Publications

From Independent Research at WSU

  • 105.  Zhao, Y.; Yang, C.; Organ, C.; Li, Z.; Bhushan, S.; Otsuka, H.; Pacheco, A.; Kang, J.; Aguilar, H. C.; Lefer, D. J.; Xian, M. Design, synthesis, and cardioprotective effects of N-mercapto-based hydrogen sulfide donors. J. Med. Chem., 2015, in press.
  • 104.  Chen, W.; Rosser, E. W.; Matsunaga, T.; Pacheco, A.; Akaike, T.; Xian, M. Development of dual-reactivity based fluorescence probes for visualizing intracellular hydrogen polysulfides signaling. Angew. Chem. Int. Ed. 2015, in press.
  • 103.  Zhang, C.; Peng, B.; Chen, W.; Shuang, S.; Xian, M.; Dong, C. A ratiometric fluorescent probe for hydrogen sulfide based on the nucleophilic substitution-cyclization of diselenides. Dyes Pigments, 2015, 121, 299-304.
  • 102.  Sattler, S. A.; Wang, X.; Lewis, K. M.; DeHan, P. J.; Park, C. M.; Xin, Y.; Liu, H.; Xian, M.; Xun, L.; Kang, C. Characterizations of two bacterial persulfide dioxygenases of the metallo-β-lactamase superfamily. J. Biol. Chem. 2015290, 18914-18923.
  • 101.  Zhao, Y.; Pacheco, A.; Xian, M. Medicinal chemistry: insights into the development of novel H2S donors. Part VIII, p365-388. P.K. Moore, M. Whiteman (eds.), Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide, Handbook of Experimental Pharmacology 230, 2015.
  • 100.  Chen, W.; Rosser, E. W.; Zhang, D.; Shi, W.; Li, Y.; Dong, W.-J.; Ma, H.; Hu, D.; Xian, M. A specific nucleophilic ring-opening reaction of aziridines as a unique platform for the construction of highly selective hydrogen polysulfide probes. Org. Lett. 201517, 2776-2779.
  • 99.  Park, C.-M.; Weerasinghe, L.; Day, J. J.; Fukuto, J. M.; Xian, M. Persulfides: current knowledge and challenges in chemistry and chemical biology. Mol. BioSyst. 201511, 1775-1785. (invited review).
  • 98.  Biggs, T. D.; Weerasinghe, L.; Park, C.-M.; Xian, M. Phosphine-mediated conjugation of S-nitrosothiols and aldehydes. Tetrahedron Lett. 2015, 56, 2741-2743.
  • 97.  Peng, B.; Zhang, C.; Marutani, E.; Pacheco, A.; Chen, W.; Ichinose, F.; Xian, M. Trapping Hydrogen Sulfide (HS) with Diselenides: The Application in the Design of Fluorescent Probes. Org Lett 2015, 17, 1541-1544.
  • 96.  Miao, Z.; Reisz, J. A.; Mitroka, S. M.; Pan, J.; Xian, M.; King, S. B. A Selective Phosphine-Based Fluorescent Probe for Nitroxyl in Living Cells. Bioorg Med Chem Lett 2015, 25, 16-19.
  • 95.  Lin, V. S.; Chen, W.; Xian, M.; Chang, C. J. Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems. Chem. Soc. Rev. 201544, 4596-4618.
  • 94.  Kim, W.; Park, C.-M.; Park, J.-J.; Akamatsu, H. O.; Peever, T. L.; Xian, M.; Gang, D. R.; Vandemark, G.; Chen, W. Functional Analyses of the Diels-Alderase Gene sol5 of Ascochyta Rabiei and Alternaria Solani Indicate That the Solanapyrone Phytotoxins Are Not Required for Pathogenicity. Mol Plant Microbe Interact 2015, 28, 482-496.
  • 93.  Park, C. M.; Xian, M. Use of phosphorodithioate-based compounds as hydrogen sulfide donors. Meth. Enzymol. 2015, 554, 127-142.
  • 92.  Peng, B.; Xian, M. Hydrogen Sulfide Detection Using Nucleophilic Substitution-Cyclization-Based Fluorescent Probes. Meth. Enzymol. 2015, 554, 47-62.
  • 91.  Park, C.-M.; Macinkovic, I.; Filipovic, M. R.; Xian, M. Chapter Three – Use of the “Tag-Switch” Method for the Detection of Protein S-Sulfhydration. Meth. Enzymol. 2015, 555, 39–56.
  • 90.  Chen, Y.; Mo, H. Z.; Zheng, M. Y.; Xian, M.; Qi, Z. Q.; Li, Y. Q.; Hu, L. B.; Chen, J.; Yang. L. F. Selenium inhibits root elongation by repressing the generation of endogenous hydrogen sulfide in Brassica rapa”. PLOS One 2014, 9, e110904.
  • 89.  Ono, K.; Akaike, T.; Sawa, T.; Kumagai, Y.; Wink, D.; Tantillo, D. J.; Hobbs, A. J.; Nagy, P.; Xian, M.; Lin, J.; Fukuto, J. M. The redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications to their possible biological activity and utility. Free Radical Biol. Med. 2014, 77, 82-94.
  • 88.  Sakaguchi, M.; Marutani, E.; Shin, H. S.; Hanaoka, K.; Chen, W.; Xian, M.; Ichinose, F. Sodium thiosulfate attenuates acute lung injury in mice. Anesthesiology 2014, 121, 1248-1257.
  • 87.  Yang, C.T.; Zhao, Y.; Xian, M.; Bai, H.; Liu, G.; Xu, J.; Zhang, M. “A novel controllable hydrogen sulfide releasing moledule protects human skin keratinocytes against methylglyoxal-induced injury and dysfunction”. Cell. Physiol. Biochem. 2014, 34, 1304-1317.
  • 86.  Liu, C.; Zhang, F.; Munske, G.; Zhang, H.; Xian, M. “Isotope dilution mass spectrometry for the quantification of sulfane sulfurs”. Free Radical Biol. Med. 2014, 76, 200-207.
  • 85.  Zhao, Y.; Kang, J.; Park, C. M.; Bagdon, P. E.; Xian, M. “Thio-activated gem-dithiols:  A new class of controllable hydrogen sulfide donors. Org Lett2014, 16, 4536-4539.
  • 84.  Marutani, E.; Chen, W.; Sasakura, K.; Liu, J.; Xian, M.; Hanaoka, K.; Nagano, T.; Ichinose, F. “Cytoprotective effects of hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonists are mediated by intracellular sulfane sulfur.” Med Chem Comm2014. 5, 1577-1583.
  • 83.  Zhang, D.; Chen, W.; Kang, J.; Ye, Y.; Zhao, Y.; Xian, M. “Highly Selective Fluorescence Off–on Probes for Biothiols and Imaging in Live Cells”. Org. Biomol. Chem. 2014, 12, 6837–6841.
  • 82.  Peng, B.; Xian, M. “Fluorescent Probes for Hydrogen Sulfide Detection”. Asian J. Org. Chem. 2014, 3, 914-924
  • 81.  Zhao, Y.; Biggs, T. D.; Xian, M. “Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications”. Chem. Commun2014, 50, 11788-11805
  • 80.  Liu, C.; Chen, W.; Shi W.; Peng, Bo; Zhao, Y. Ma, H.; Xian, M. “Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides” J. Am. Chem. Soc., 2014, 136, 7257-7260.
  • 79.  Ida, T.; Sawa, T.; Ihara, H.; Tsuchiya, Y.; Watanabe, Y.; Kumagai, Y.; Suematsu, M.; Motohashi, H.; Fujii, S.; Matsunaga, T.; Yamamoto, M.; Ono, K.; Devarie-Baez, N. O.; Xian, M.; Fukuto, J. M.; Akaike, T. “Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling”. Proc. Natl. Acad. Sci. USA2014, 111, 7606-7611.
  • 78.  Zhang, D.; Chen, W.; Miao, Z.; Ye, Y.; Zhao, Y.; King, S. B.; Xian, M. “A reductive ligation based fluorescent probe for S-nitrosothiols”. Chem. Commun.2014,50, 4806-4809
  • 77.  Li, Y.-J.; Chen, J.; Xian, M.; Zhou, L.-G.; Han, F. X.; Gan, L.-J.; Shi, Z.-Q. “In site bioimaging of hydrogen sulfide uncovers its pivotal role in regulating nitric oxide-induced lateral root formation.” PLOS One20149, e90340.
  • 76.  Zhang, D.; Macinkovic, I.; Devarie-Baez, N. O.; Pan, J.; Park, C.-M.; Carroll, K. S.; Filipovic, M. R.; Xian, M. “Detection of Protein S-Sulfhydration by a Tag-Switch Technique.” Angew. Chem. Int. Ed201453, 575 –581. (selected as a hot paper for the months, January/February, of European Network on Gasotransmitters)
  • 75.  Peng, B.; Chen, W.; Liu, C.; Rosser, E. W., Pacheco, A.; Zhao, Y.; Aguilar, H. C.; Xian, M. “Fluorescent probes on nucleophilic substitution-cyclization for hydrogen sulfide detection and bioimaging.” Chem. Eur. J. 201420, 1010 – 1016.
  • 74.  Park, C.-M.; Zhao, Y.; Zhu, Z.; Pacheco, A.; Peng, B. Devarie-Baez, N.; Bagdon, P.; Zhang, H.; Xian, M. “Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors” Mol. BioSys. 2013, 9, 2430-2434
  • 73.  Devarie-Baez, N.; Bagdon, P.; Peng, B.; Zhao, Y.; Park, C.-M., Xian, M. “Light-induced hydrogen sulfide release from “Caged” gem-dithiols” Org. Lett2013, 15, 2786-2789.
  • 72.  Chen, W.; Liu, C.; Peng, B.; Zhao, Y.; Pacheco, A.; Xian, M. “New fluorescent probe for sulfane sulfurs and the application in bioimaging” Chemical Science 2013, 4, 2892-2896.  (highlighted in ChemistryWorld).
  • 71.  Devarie, N. O.; Zhang, D.; Li, S.; Whorton, A. R. Xian, M. “Direct methods for the detection of protein S-nitrosation”. Methods 2013, 62, 171-176.
  • 70.  Zhao, Y.; Bhushan, S.; Yang, C.; Otsuka, H.; Stein, J. D.; Pacheco, A.; Peng, B.; Devarie, N. O.; Aguilar, H. C.; Lefer, D. J.; Xian, M. “Controllable hydrogen sulfide donors and the activity against myocardial ischemia-reperfusion injury” ACS Chem. Biol. 2013, 8, 1283-1290. (highlighted in C&EN)
  • 69.  Markand, S.; Tawfik, A.; Ha, Y.; Gnana-Prakasam, J.; Sonne, S.; Ganapathy, V.; Sen, N.; Xian, M.; Smith, S. B. “Cystathionine beta synthase expression in mouse retina”. Curr. Eye. Res201338, 597-604.
  • 68.  Talipov, M. R.; Khomyakov, D. G.; Xian, M.; Timerghazin, Q. K. “Computational design of S-nitrosothiol ‘Click’ reactions”. J. Comput. Chem2013. 34, 1527-1530.
  • 67.  Zhang, D.; Devarie-Baez, N. O.; Li, Q.; Lancaster, J. R. Jr.; Xian, M. “Methylsulfonyl benzothiozole (MSBT): a selective protein thiol blocking reagent”. Org. Lett201214, 3396.
  • 66.  Park, C. –M.; Niu, W.; Liu, C.; Biggs, T. D.; Guo, J.; Xian, M. “A proline based phosphine template for Staudinger ligation”. Org. Lett201214, 4697.
  • 65.  Liu, C.; Peng, B.; Li, S.; Park, C. –M.; Whorton, A. R.; Xian, M. “Reaction based fluorescent probes for hydrogen sulfide”. Org. Lett201214, 2184.
  • 64.  Li, S.; Wang, H.; Xian, M.; Whorton, A. R. “Identification of protein nitrosothiols using phosphine-mediated selective reduction”. Nitric Oxide 201226, 20.
  • 63.  Liu, C.; Pan, J.; Li, S.; Zhao, Y.; Wu, L. Y.; Berkman, C. E.; Whorton, A. R.; Xian, M. “Capture and visualization of hydrogen sulfide by a fluorescent probe”. Angew. Chem. Int. Ed. 201150, 10327.
  • 62.  Pan, J.; Devarie, N. O.; Xian, M. “Facile amide formation via S-nitrosothioacids”. Org. Lett. 201113, 1092.
  • 61.  Liu, X.; Wang, Y.; Cao, Y.; Yadama, V.; Xian, M.; Zhang, J. “Study of dextrin-derived curing agent for waterborne epoxy adhesive. Carbohyd. Polym201183, 1180.
  • 60.  Zhao, Y.; Wang, H.; Xian, M. “Cysteine activated hydrogen sulfide (H2S) donors”. J. Am. Chem. Soc2011133, 15.
  • 59.  Wang, H.; Xian, M. “Chemical methods to detect S-nitrosation”. Curr. Opin. Chem. Biol. 201115, 32.
  • 58.  Pan, J.; Xian, M. “Disulfide formation via sulfenamides”. Chem. Commun2011, 352. (Emerging Investigators Issue).
  • 57.  Zhang, D. H.; Davarie-Baez, N. O.; Pan, J.; Wang, H.; Xian, M. “One-pot thioether formation from S-nitrosothiols“. Org. Lett201012, 5674.
  • 56.  Zhang, J.; Li, S.; Zhang, D.; Wang, H.; Whorton, R.; Xian, M. “Reductive ligation mediated one-step disulfide formation of S-nitrosothiols“. Org. Lett. 201012, 4208.
  • 55.  Devarie, N.; Xian, M. “Facile preparation of 3-substituted benzisothiazoles from o-mercapto-acylphenones”. Org. Lett201012, 752.
  • 54.  Wang, H.; Zhang, J.; Xian, M. “Facile formation of dehydroalanine from S-nitrosocysteines”. J. Am. Chem. Soc. 2009131, 13238.
  • 53.  Wang, H.; Liu, X.; Liu, B.; Zhang, J.; Xian, M. “Synthesis of rosin-based flexible anhydride type curing agents and properties of the cured epoxy”. Polym. Int200958, 1435.
  • 52.  Zhang, J.; Wang, H.; Xian, M. “An unexpected bis-ligation of S-nitrosothiols”. J. Am. Chem. Soc. 2009131, 3854. (this work is featured by Chemical & Engineering News 2009, March 16, Vol 87).
  • 51.  Devarie, N.; Kim, W.; Smith, A. B. III, Xian, M. “Multicomponent type II anion relay chemistry (ARC): one-pot syntheses of 2,3-disubstituted furans and thiophenes exploiting 2-trialkylsilyl-3-formyl bifunctional linchpins”. Org. Lett. 200911, 1861.
  • 50.  Pan, J.; Downing, J. A.; McHale, J. L.; Xian, M. “A fluorogenic dye activated by S-nitrosothiols”. Mol. BioSyst20095, 918. (Emerging Investigators Issue)
  • 49.  Zhang, J.; Wang, H.; Xian, M. “Exploration of the traceless reductive ligation of S-nitrosothiols”. Org. Lett. 200911, 477.
  • 48.  Wang, H.; Liu, B.; Liu, X.; Zhang, J.; Xian, M. “Synthesis of biobased epoxy and curing agents using rosin and study of cure reactions”. Green Chem. 200810, 1190.
  • 47.  Wang, H.; Shuhler, B. J.; Xian, M. “Total synthesis of diospongins A and B”. Synlett 2008, 2651.
  • 46.  Wang, H.; Xian, M. “Fast reductive ligation of S-nitrosothiols”. Angew Chem. Int. Ed200847, 6598.
  • 45.  Xian, M.; Zhu, C-J. “2-[Bis-(3,5-bistrifluoromethyl)-phenyl]-[(trimethylsilyl)oxy]-methyl]-pyrrolidine.” Encyclo. Reagents for Org. Syn. 2008.
  • 44.  Devarie, N.; Shuhler, B. J.; Wang, H.; Xian, M. “Solvent controlled C(sp2)O silyl migration: the one-pot synthesis of 2,3-disubstituted thiophenes”  Org. Lett20079, 4655.
  • 43.  Wang, H.; Shuhler, B. J. Xian, M. “A versatile strategy for the synthesis of 2,6-disubstituted dihydropyranones” J. Org. Chem200772, 4280.
  • 42.  Xian, M.; Shuhler, B. J. “Study of the synthesis of poecillanosine” Tetrahedron Lett. 200748, 1209.
    Publications from postdoctoral research (UPenn)
  • 41.  Shaw, S. J.; Menzella, H. G.; Myles, D. C.; Xian, M.; Smith, A. B., III. “Coumarin-derived discodermolide analogues possessing equivalent antiproliferative activity as the natural product-a further simplification of the lactone region” Org. Biomol. Chem., 2007, 5, 2753.
  • 40.  Smith, A. B., III; Kim, D.-S.; Xian, M. “Anion relay chemistry extended.  Synthesis of a gorgonian sesquiterpene” Org. Lett. 2007, 9, 3307.
  • 39.  Smith, A. B., III; Xian, M.; Kim, W. –S.; Kim, D.-S. “The 1,5-Brook rearrangement: an initial application in anion relay chemistry” J. Am. Chem. Soc. 2006, 128, 12368.
  • 38.  Smith, A. B., III; Xian, M. “Anion relay chemistry: an effective tactic for diversity oriented synthesis” J. Am. Chem. Soc. 2006, 128, 66. (This work is featured by Chemical & Engineering News 2006, January 2, Vol 84).
  • 37.  Smith, A. B., III; Xian, M. “Design, synthesis and biological evaluation of simplified analogues of discodermolide, additional insights on the importance of the diene, the C(7) hydroxyl, and the lactone” Org. Lett. 2005, 7, 5229.
  • 36.  Smith, A. B., III; Xian, M.; Liu, F. “Design, total synthesis and evaluation of C13,C14 cyclopropane analogues of discodermolide” Org. Lett. 2005, 7, 4613.
  • 35.  Shaw, S. J.; Sundermann, K. F.; Burlingame, M. A.; Myles, D. C.; Freeze, B. S.; Xian, M.; Brouard, I.; Smith, A. B., III. “Toward understanding how the lactone moiety of discodermolide affects activity” J. Am. Chem. Soc. 2005, 127, 6532.
  • 34.  Smith, A. B., III; Freeze, B. S.; Xian, M.; Hirose, T. “Total synthesis of (+)-Discodermolide: A highly convergent fourth-generation approach” Org. Lett. 2005, 7. 1825.
  • 33.  Smith, A. B., III; Freeze, B. S.; LaMarche, M. J.; Hirose, T.; Brouard, I.; Xian, M.; Myles, D. C.; Sundermann, K. F.; Shaw, S. J.; Burlingame, M. A. “Design, synthesis and evaluation of analogues of (+)-14-normethyldiscodermolide” Org. Lett. 2005, 7, 315.
  • 32.  Smith, A. B. III; Freeze, B. S.; LaMarche, M. J.; Hirose, T.; Brouard, I.; Rucker, P. V.; Xian, M.; Myles, D. C.; Sundermann, K. F.; Shaw, S. J.; Burlingame, M. A. “Carbamate-substituted analogues of (+)-discodermolide” Org. Lett. 2005, 7, 311.
    Publications from graduate research (Nankai & Wayne State)
  • 31.  Zhu, L.; Kedenburg, J.; Xian, M.; Wang, P. G. “A systematic strategy for preparation of uncommon sugars through enzymatic resolution and ring closing metathesis” Tetrahedron Lett., 2005, 46, 811-813.
  • 30.  Cheng, H.; Xian, M.; Wu, J.; Tunac, J. B.; Sun, D.; Wang, P. G. “Synthesis and enzyme-specific activation of carbohydrate-geldanamycin conjugates with potent anticancer activity” J. Med. Chem. 2005, 48, 645-652.
  • 29.  Xian, M.; Fatima, Z.; Zhang, W.; Fang, J.; Pei, D.; Loo, J.; Stevenson, T.; Wang, P. G. “Identification of alpha-Gal epitope mimetics through rapid generation and screening of C-linked glycopeptide library” J. Comb. Chem. 2004, 6, 126-134.
  • 28.  Jia, Q.; Cai, T.; Huang, M. Li, H.; Xian, M.; Poulos, T. L.; Wang, P. G. “Isoform-selective substrates of nitric oxide synthases” J. Med. Chem., 2003, 46, 2271.
  • 27.  Li, H.; Shimizu, H.; Flinspach, M.; Jamal, J.; Yang, W.; Xian, M.; Cai, T.; Wen, Z.; Jia, Q.; Wang, P. G.; Poulos, T. L. “The novel binding mode of N-alkyl-N’-hydroxyguanidine to nNOS provide mechanistic insights into NO biosynthesis” Biochemistry 2002, 41, 13868.
  • 26.  Jia, Q.; Janczuk, A.; Cai, T.; Xian, M.; Wen, Z.; Wang, P. G. “NO donors with anticancer activity” Expt. Opin. Therap. Pat. 2002. 12, 819.
  • 25.  Cai, T. W.; Xian, M.; Wang, P. G. “Electrochemical and peroxidase oxidation study of N-hydroxyguanidine derivatives as NO donors” Bioorg. Med. Chem. Lett. 2002, 12, 1507.
  • 24.  Wu, X.; Tang, X.; Xian, M.; Brauschweiger, P. G.; Wang, P. G. “Synthesis and cytotoxicities of mannose conjugated SNAP” Bioorg. Med. Chem. 2002, 10, 2303.
  • 23.  Xian, M.; Fujiwara, N.; Cai, T.; Wen, Z.; Kazuma, S.; Janczuk, A.; Tang, X.; Telyatnikov, V.; Miyamoto, Y.; Taniguchi, N.; Wang, P. G. “Novel substrates for nitric oxide synthases” Bioorg. Med. Chem. 2002, 10, 3049-3055.
  • 22.  Wang, P. G.; Xian, M.; Tang, X. -P.; Wu, X. –J; Wen, Z.; Cai, T. –W. “Nitric oxide donors: chemical activities and biological applications” Chem. Rev. 2002, 102, 1091.
  • 21.  Chen, X. C.; Wen, Z.; Xian, M.; Wang, K.; Ramachandran, N.; Schlegel, H. B.; Mutus, B.; Wang, P. G.  “Fluorophore-labeled S-nitrosothiols”  J. Org. Chem., 2001, 66, 6064.
  • 20.  Xian, M.; Li, X. P.; Tang, X. P.; Chen, X. C.; Zheng, X. L.; Galligan, J. J.; Kreulen, D. L.; Wang, P. G.  “N-hydroxyl derivatives of guanidine based drugs as enzymatic NO donors”  Bioorg. Med. Chem. Lett. 2001, 11, 2377-2380.
  • 19. Wu, X. J.; Tang, X. P.; Xian, M.; Wang, P. G.  “Glycosylated diazeniumdiolates: a novel class of enzyme-activated nitric oxide donors”  Tetrahedron Lett. 2001, 42, 3779.
  • 18. Tang, X. P.; Xian, M.; Trikha, M.; Honn, K. V.; Wang, P. G. “Synthesis of peptide-diazeniumdiolate conjugates: towards enzyme activated antitumor agents”  Tetrahedron Lett. 2001, 42, 2625.
  • 17. Wang, K.; Wen, Z.; Zhang, W.; Xian, M.; Cheng, J. P.; Wang, P. G.  “Equilibrium and kinetics studies of transnitrosation between S-nitrosothiols and thiols”  Bioorg. Med. Chem. Lett. 2001, 11, 433.
  • 16. Guo, Z.-M.; Xian, M.; Zhang, W.; McGill, A.; Wang, P. G.  “N-Nitrosoanilines: A new class of caspase-3 inhibitors”  Bioorg. Med. Chem. 2001, 9, 99.
  • 15. Zhu, X.-Q.; He, J.; Li, Q.; Xian, M.; Lu, J. M.; Cheng, J.-P. “N-NO bond dissociation energies of N-nitroso diphenylamine derivatives (or analogues) and their radical anions: Implications for the effect of reductive electron transfer on N-NO bond activation and for the mechanisms of NO transfer to nitranions” J. Org. Chem. 2000, 65, 6729.
  • 14. Lu, J.; Zhu, X.; Li, Q.; He, J.; Xian, M.; Cheng, J.-P. “Determination of heterolytic and homolytic S-NO bond dissociation energies in acetonitrile” Chem. J. Chin. Univ. 2000, 21, 570.
  • 13. Xian, M.; Wang, M.; Chen, X.-C.; Wang, K.; Wang, P. G. “S-Nitrosothiols as novel, reversible inhibitors of human rhinovirus 3C protease” Bioorg. Med. Chem. Lett. 2000, 10, 2097-2100.
  • 12. Xian, M.; Chen, X. -C.; Liu, Z.; Wang, K.; Wang, P. G.  “Inhibition of papain by S-nitrosothiols: formation of mixed disulfides”  J. Biol. Chem. 2000, 275, 20467-20473.
  • 11. Wang, K.; Zhang, W.; Xian, M.; Chen, X. –C.; Cheng, J. –P.; Wang, P. G. “New chemical and biological aspects of S-nitrosothiols” Curr. Med. Chem. 2000. 7, 821.
  • 10. Xian, M.; Zhu, X. –Q.; Lu, J. –M.; Wen, Z.; Cheng, J. –P. “The first O-NO bond energy scale in solution: heterolytic and homolytic cleavage enthalpies of O-nitrosyl carboxylate compounds”. Org. Lett. 2000, 2, 265-268.
  • 9. Xian, M.; Wang, K.; Chen, X. –C.; McGill, A.; Zhang, Z. –Y.; Cheng, J. –P.; Wang, P. G. “Inhibition of protein tyrosine phosphatases by low-molecular-weight S-nitrosothiols and S-nitrosylated human serum albumin”.  Biochem. Biophys. Res. Commun. 2000, 268, 310-314.
  • 8. Wang, K.; Hou, Y. C.; Zhang, W.; Ksebati, M. B.; Xian, M.; Cheng, J. –P.; Wang, P. G. “N15 NMR and electronic properties of S-nitrosothiols”.  Bioorg. Med. Chem. Lett.  1999, 9, 2897.
  • 7. Zhu, X. –Q.; Xian, M.; Wang, K.; Cheng, J. –P. “Is NO (nitric oxide) an electron acceptor or an electrophile? A detailed thermodynamic investigation on the mechanisms of NO-initiated reactions with 3,6-dibromocarbazolide anion and related carbanion”. J. Org. Chem. 1999, 64, 4187-4190.
  • 6. Xian, M.; Zhu, X. –Q.; Li, Q.; Cheng, J. –P. “A high-yielding and facile preparation of N-substituted thioureas by substitution of nitrosothioureas with alkylamines”.  Tetrahedron. Lett. 1999, 40, 1957.
  • 5. Cheng, J. -P.; Xian, M.; Wang, K.; Zhu, X. –Q.; Yin, Z.; Wang, P. G. “Heterolytic and homolytic Y-NO bond energy scales of nitroso-containing compounds: Chemical origin of NO release and NO capture”  J. Am. Chem. Soc. 1998, 120, 10266-10267.
  • 4. Xian, M.; Lu, J. –M.; Zhu, X. –Q.; Mu, L. –J.; Cheng, J. –P. “ A facile and high-yielding preparation of 1-aryl-3,3-dialkylureas”. J. Chem. Res. (S). 1998, 442.
  • 3. Lu, Y.; Xian, M.; Zhu, X. –Q.; Mu, L. -J.; Cheng, J. P. “Studies on structure-reactivity relationship for NAD(P)H model compounds: Electronic effect of the 3-acyls”. Chem. J. Chinese. U. 1999, 20, 59.
  • 2. Lu, Y.; Xian, M.; Cheng, J. –P.; Xia, C. –Z. “Investigation on the reduction of carbocations by BNAH – Kinetics, thermodynamics, and reaction mechanisms”.  Acta. Chim. Sinica. 1997, 55, 1145.
  • 1. Lu, Y.; Xian, M.; Cheng, J. –P. “Studies on the Mg2+-catalyzed reductions of N-arylfluorenimines by NAD(P)H models”.  Chem. J. Chinese. U. 1997, 18, 1484.